Toxicity Studies

Standard Toxicity Studies e.g. for REACH

Our toxicity tests will be performed in accordance with the OECD guidelines that are used, for example, in the REACH testing programs. We also test your food additive and nutrient sources according to the recent Guidance for submission for food additive evaluations of EFSA.

In addition, we can expand our study protocols to be in accordance to the ICH guideline S8, „Immunotoxicity studies for Human Pharmaceuticals“ as well as to EMA guidelines.

We perform the following tests routinely in rodents:

• OECD 402 – Acute Dermal Toxicity
• OECD 407 – Repeated Dose 28-day Oral Toxicity Study in Rodents
• OECD 408 – Repeated Dose 90-Day Oral Toxicity Study in Rodents
• OECD 410 – Repeated Dose Dermal Toxicity: 21/28-day Study
• OECD 411 – Subchronic Dermal Toxicity: 90-day Study
• OECD 414 – Prenatal Development Toxicity Study
• OECD 416 – Two-Generation Reproduction Toxicity
• OECD 420 – Acute Oral Toxicity – Fixed Dose Procedure
• OECD 421 – Reproduction/Developmental Toxicity Screening Test
• OECD 422 – Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
• OECD 423 – Acute Oral toxicity – Acute Toxic Class Method
• OECD 442 B – Skin Sensitization
• OECD 443 – Extended One-Generation Reproductive Toxicity Study
• OECD 451 – Carcinogenicity Studies
• OECD 452 – Chronic Toxicity Studies
• OECD 453 – Combined Chronic Toxicity/Carcinogenicity Studies

All OECD safety guidelines on health effects can be downloaded here. If your test is not listed above, please call us for additional tests.