REACH Tests

Standard Toxicity Tests for REACH

vivo Science offers the standard toxicity tests in accordance to selected OECD guidelines in rodents in addition to the immunological testing.

These studies will be fully compliant to use for the registration of your chemical with REACH at the European Chemicals Agency ECHA.

For example, the following OECD tests can be performed in rodents:

• 402 Acute dermal toxicity
• 407 Repeated dose 28-day oral toxicity study
• 408 Repeated dose 90-Day oral toxicity study
• 410 Repeated dose dermal toxicity 21/28-day study
• 414 Prenatal developmental toxicity study
• 420 Acute oral toxicity – fixed dose method
• 421 Reproduction/developmental toxicity screening test
• 422 Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
• 423 Acute oral toxicity – acute toxic class method
• 425 Acute oral toxicity, up-and-down procedure

You´ll find all recent OECD Health Effects Guidelines here.

The OECD standard protocols can be expanded to include immuno-toxicological testing in accordance to the recent ICH guidance S8 (“Immuntoxicity studies to human pharmaceuticals”) at any time.  Moreover, our rodent housing capabilities allow the application of your lead substances to immunodeficient animal models if required. Please request additional information if required.